GuidGuide.com Provided Information

In the creation of components for Microsoft Windows using COM, all components must implement the IUnknown interface in order to allow client code to find all other interfaces and features of that component, and they do this by creating a GUID which may be called upon to provide an entry point. The IUnknown interface is defined as a GUID with the value of {00000000-0000-0000-C000-000000000046}, and rather than having a named entry point called "IUnknown", the preceding GUID is used, thus every component that provides an IUnknown entry point gives the same GUID, and every program that looks for an IUnknown interface in a component always uses that GUID to find the entry point, knowing that an application using that particular GUID must always consistently implement IUnknown in the same manner and the same way.

Source: http://en.wikipedia.org/wiki/Globally_Unique_Identifier